4932. Indanazoline

Nomenclature

CAS number: 40507-78-6
N-(2,3-Dihydro-1H-inden-4-yl)-4,5-dihydro-1H-imidazol-2-amine; N-(2-imidazolin-2-yl)-N-(4-indanyl)amine.
C12H15N3; mol wt 201.27.
C 71.61%, H 7.51%, N 20.88%.

Description and references

Prepn: H. J. May, A. Berg, DE 2136325; eidem, US 3882229 (1973, 1975 both to Nordmark); H. J. May, Arzneim.-Forsch. 30, 1733 (1980). Toxicity data: W. Worstmann et al., ibid. 1760. Series of articles on galenical development, pharmacology, pharmacokinetics and toxicity: ibid. 1738-1787.

Chemical structure

Properties

Crystals from petr ether, mp 109-113°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 40507-80-0
E-VA-16; Farial (Riemser).
C12H15N3.HCl; mol wt 237.73.
C 60.63%, H 6.78%, N 17.68%, Cl 14.91%.

Properties

Crystals from isopropanol, mp 182-184°. LD50 in male, female mice (mg/kg): 179, 233 orally; 22.3, 26.9 i.v.; in male, female rats: 481, 542 orally; 16.3, 17.6 i.v. (Worstmann).

Therapeutic Category

Decongestant (nasal).

Keywords

α-Adrenergic Agonist; Decongestant