Description and references

Non-selective β-adrenergic blocker. Prepn: M. Murakami et al., DE 1955229; eidem, US 4045482 (1970, 1977 both to Yamanouchi); K. Murase et al., Yakugaku Zasshi 92, 1358 (1972), C.A. 78, 71723 (1973). Indenolol is a tautomeric mixture of the 7- and 4-indenyloxy isomers in a 2:1 ratio, respectively. Unambiguous synthesis of the two isomers: eidem, Chem. Pharm. Bull. 24, 552 (1976). β-Blocking and cardiovascular properties: T. Takenaka, S. Tachikawa, Arzneim.-Forsch. 22, 1864 (1972). General pharmacology: M. Takeda et al., Oyo Yakuri 7, 469 (1973), C.A. 80, 44015 (1974). Comparative pharmacological study with other β-blockers: W. Bartsch et al., Arzneim.-Forsch. 27, 1022 (1977). Dose-response studies: F. E. Okupa et al., Clin. Pharmacol. Ther. 29, 434 (1981). Pharmacokinetics: R. Sega et al., J. Clin. Pharmacol. 25, 337 (1985). Clinical evaluation in hypertension: B. Trimarco et al., ibid. 328; L. Poggesi et al., Clin. Pharmacol. Ther. 41, 344 (1987).

Properties

Derivative