4983. Insulin Detemir

Nomenclature

CAS number: 169148-63-4
29B-[N6-(1-Oxotetradecyl)-l-lysine](1A-21A),(1B-29B)-insulin (human); 29B-(N6-myristoyl-l-lysine)-30B-de-l-threonineinsulin (human); LysB29-tetradecanoyl, des(B30)-insulin; NN-304; Levemir (Novo).
C267H402N64O76S6; mol wt 5916.82.
C 54.20%, H 6.85%, N 15.15%, O 20.55%, S 3.25%.

Description and references

Soluble long-acting basal insulin analog. Prepn: S. Havelund et al., WO 9507931 (1995 to Novo Nordisk); and albumin binding affinity: P. Kurtzhals et al., Biochem. J. 312, 725 (1995). Clinical pharmacokinetics: T. Danne et al., Diabetes Care 26, 3087 (2003). Pharmacodynamic profile: J. Plank et al., ibid. 28, 1107 (2005). Clinical comparison with NPH insulin in type 1 diabetes: P. Home et al., ibid. 27, 1081 (2004). Review of pharmacology and clinical experience: P. Home, P. Kurtzhals, Expert Opin. Pharmacother. 7, 325-343 (2006).

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic; Hormones/Analogs