5042. Iodoquinol

Nomenclature

CAS number: 83-73-8
5,7-Diiodo-8-quinolinol; diiodohydroxyquin; diiodo-oxyquinoline; 5,7-diiodo-8-hydroxyquinoline; SS-578; Diodoquin (Searle); Disoquin; Floraquin (Searle); Dyodin; Dinoleine; Searlequin; Diodoxylin; Rafamebin; Ioquin (Abbott); Direxiode (Delalande); Stanquinate; Yodoxin (Searle); Zoaquin; Enterosept; Embequin (M & B).
C9H5I2NO; mol wt 396.95.
C 27.23%, H 1.27%, I 63.94%, N 3.53%, O 4.03%.

Description and references

Prepd by the action of iodine monochloride on 8-hydroxyquinoline: Papesch, Burtner, J. Am. Chem. Soc. 58, 1314 (1936); by the action of KIO3 on 8-hydroxyquinoline: Zeifman, C.A. 34, 3745. Electrolytic prepn: Brown, Berkowitz, Trans. Electrochem. Soc. 75, 385 (1939). See also Claus, DE 78880; Passek, DE 411050; Matsumura, C.A. 21, 1461 (1927); Pirrone, Cherubino, C.A. 28, 3073 (1934).

Chemical structure

Properties

Crystals from xylene. The medicinal grade is a yellowish-brown powder. mp 200-215° (extensive decompn). Almost insol in water. Sparingly sol in alcohol, ether, and acetone; sol in hot pyridine and in hot dioxane.

Therapeutic Category

Antiamebic.

Keywords

Antiamebic