5051. Ioglycamic Acid

Nomenclature

CAS number: 2618-25-9
3,3′-[Oxybis[(1-oxo-2,1-ethanediyl)imino]]bis[2,4,6-triiodobenzoic acid]; 3,3′-[oxybis(methylenecarbonylimino)]bis[2,4,6-triiodobenzoic acid]; 3,3′-(diglycoloyldiimino)bis(2,4,6-triiodobenzoic acid); diglycolic acid bis(2,4,6-triiodo-3-carboxanilide); N,N-(oxydiacetyl)bis[3-amino-2,4,6-triiodobenzoic acid].
C18H10I6N2O7; mol wt 1127.71.
C 19.17%, H 0.89%, I 67.52%, N 2.48%, O 9.93%.

Description and references

Prepn: Priewe et al., Ber. 87, 651 (1954); Priewe, Rutkowski, US 2776241; US 2853424 (1957, 1958 both to Schering AG).

Chemical structure

Properties

Occurs in three cryst modifications: Neudert, Rpke, Helv. Chim. Acta 41, 855 (1958). mp with baking at 222°, sintering at 227°, splitting of iodine at 245°, dec 281°.

Derivative

Meglumine salt.

Nomenclature

CAS number: 14317-18-1
Dimeglumine ioglycamide; Biligram (Schering AG).
C18H10I6N2O7.2(C7H17NO5); mol wt 1518.14.
C 25.32%, H 2.92%, I 50.16%, N 3.69%, O 17.92%.

Properties

Water soluble.

Therapeutic Category

Diagnostic aid (radiopaque medium—cholecystographic).

Keywords

Diagnostic Aid (Radiopaque Medium)