5053. Iomeglamic Acid

Nomenclature

CAS number: 25827-76-3
5-[(3-Amino-2,4,6-triiodophenyl)methylamino]-5-oxopentanoic acid; 3′-amino-2′,4′,6′-triiodo-N-methylglutaranilic acid; N-methyl-N-(3-amino-2,4,6-triiodophenyl)glutaramic acid; N-methyl-N-(2,4,6-triiodo-3-aminophenyl)glutaramidic acid; RG-270; Falignost (Hexal).
C12H13I3N2O3; mol wt 613.96.
C 23.48%, H 2.13%, I 62.01%, N 4.56%, O 7.82%.

Description and references

Prepn: Cassebaum, Dierbach, DD 67209 (1969), C.A. 72, 66654j (1970). Biotransformation: Pfeifer et al., Pharmazie 27, 403 (1972). Pharmacology: H. Bekker et al., ibid. 411. Clinical evaluation: Barke, Zentralbl. Pharm. Pharmakother. Laboratoriumsdiagn. 110, 1117 (1971).

Chemical structure

Properties

Yellow to brown crystals from acetic acid, mp 169°. Freely sol in DMF; slightly sol in ethanol, chloroform. Practically insol in water. LD50 i.v. in mice: 500 mg/kg (Bekker).

Therapeutic Category

Diagnostic aid (radiopaque medium—cholecystographic).

Keywords

Diagnostic Aid (Radiopaque Medium)