5060. Iophendylate

Nomenclature

CAS number: 99-79-6
4-Iodo-ι-methylbenzenedecanoic acid ethyl ester; ethyl 10-(p-iodophenyl)undecylate; ethyl 10-(p-iodophenyl)hendecanoate.
C19H29IO2; mol wt 416.34.
C 54.81%, H 7.02%, I 30.48%, O 7.69%.

Description and references

Chief component of Ethiodan, Mulsopaque, Myodil, Neurotrast, Pantopaque; may also contain other isomers including 11-(p-iodophenyl)undecylate. Prepn: W. H. Strain et al., J. Am. Chem. Soc. 64, 1436 (1942); eidem, US 2348231 (1944 to Noned Corp. and Kodak); W. Baker et al., J. Soc. Chem. Ind. 63, 223 (1944). Pharmacology and toxicity: T. B. Steinhausen et al., Radiology 43, 230 (1944). Clinical evaluation of diagnostic use in myelography: G. H. Ramsey et al., ibid. 236. Clinical comparison with metrizamide, q.v., in diagnostic radiology: S. A. Keiffer et al., ibid. 129, 695 (1978). Evaluation of use in MR imaging of the spine: I. F. Braun et al., Am. J. Neuroradiol. 7, 997 (1986); A. K. Anand et al., Comput. Radiol. 11, 165 (1987).

Chemical structure

Properties

Viscous liquid. Darkens slowly in air. d2020 1.240-1.263. nD25 1.5230-1.5280. Saponif equiv 395-420. Very slightly sol in water. Freely sol in alcohol, benzene, chloroform, ether. LD50 in mice, rats (g/kg): 4.6, 19 i.p. (Steinhausen).

Therapeutic Category

Diagnostic aid (radiopaque medium).

Therapeutic Category (Veterinary)

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)