5067. Ioxaglic Acid

Nomenclature

CAS number: 59017-64-0
3-[[[[3-(Acetylmethylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoyl]amino]acetyl]amino]-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodobenzoic acid; N-(2-hydroxyethyl)-2,4,6-triiodo-5-[2-[2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido]acetamido]isophthalamic acid; P-286.
C24H21I6N5O8; mol wt 1268.88.
C 22.72%, H 1.67%, I 60.01%, N 5.52%, O 10.09%.

Description and references

Ionic contrast medium of low osmolality. Prepn: G. Tilly et al., DE 2523567; eidem, US 4014986 (1975, 1977 both to Guerbet). Effect on peripheral arterial blood flow in dogs: R. M. Steiner et al., Clin. Radiol. 31, 621 (1980). Effect on thyroid function: R. G. Grainger, G. W. Pennington, Br. J. Radiol. 54, 768 (1981). Clinical study in femoral angiography: S. Suzuki et al., Acta Radiol. 23, 87 (1982); in cardiac radiology: R. L. Feldman, Am. J. Cardiol. 61, 1334 (1988). Toxicity study: M. Sovak et al., Invest. Radiol. 16, 438 (1981). Mutation study: W. Hadnagy et al., Mutat. Res. 104, 249 (1982).

Chemical structure

Derivative

Mixture of meglumine and sodium salts.

Nomenclature

CAS number: 76820-74-1
MP-302; Hexabrix (Guerbet).

Therapeutic Category

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)