5075. Iprindole

Nomenclature

CAS number: 5560-72-5
6,7,8,9,10,11-Hexahydro-N,N-dimethyl-5H-cyclooct[b]indole-5-propanamine; 5-[3-(dimethylamino)propyl]-6,7,8,9,10,11-hexahydro-5H-cyclooct[b]indole; 1-(3-dimethylaminopropyl)-2,3-hexamethyleneindole; pramindole (obsolete); Tertran (Wyeth).
C19H28N2; mol wt 284.44.
C 80.23%, H 9.92%, N 9.85%.

Description and references

Prepn: L. M. Rice, M. E. Freed, BE 623933; eidem, US 3282942 (1963, 1966, both to Am. Home Prods.); Rice et al., J. Med. Chem. 7, 313 (1964). Pharmacology: Gluckman, Baum, Psychopharmacologia 15, 169 (1969); Baum et al., Eur. J. Pharmacol. 13, 287 (1971). Mechanism of action: Miller et al., Experientia 26, 863 (1970); Lemberger et al., Biochem. Pharmacol. 19, 3021 (1970). Freeman, Sulser, J. Pharmacol. Exp. Ther. 183, 307 (1972).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 20432-64-8
Wy-3263; Prondol (Wyeth); Galatur (Wyeth).
C19H28N2.HCl; mol wt 320.90.
C 71.11%, H 9.11%, N 8.73%, Cl 11.05%.

Properties

Crystals from methanol + acetone, mp 146-147°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics