5110. Isoaminile

Nomenclature

CAS number: 77-51-0
α-[2-(Dimethylamino)propyl]-α-(1-methylethyl)benzeneacetonitrile; 4-(dimethylamino)-2-isopropyl-2-phenylvaleronitrile; 3-cyano-5-dimethylamino-3-phenyl-2-methylhexane; α-(β-dimethylaminopropyl)-α-isopropylphenylacetonitrile; Aprecon; Dimyril; Nullatuss.
C16H24N2; mol wt 244.38.
C 78.64%, H 9.90%, N 11.46%.

Description and references

Prepn: GB 822695; Stühmer, Funke, US 2934557 (1959, 1960, both to Kali-Chemie).

Chemical structure

Properties

Liquid, bp3 138-146°.

Derivative

Citrate.

Nomenclature

CAS number: 28416-66-2
Perocan (Toyo Jozo).
C16H24N2.C6H8O7; mol wt 436.50.
C 60.54%, H 7.39%, N 6.42%, O 25.66%.

Properties

Crystals from alcohol + ether, mp 63-64°.

Derivative

Cyclamate.

Nomenclature

CAS number: 10075-36-2
Mucalan; Peracon (Kali-Chemie).
C22H37N3O3S; mol wt 423.61.
C 62.38%, H 8.80%, N 9.92%, O 11.33%, S 7.57%.

Description and references

Prepn: Dickinson, US 3074996 (1963 to Abbott).

Derivative

Tartrate.
C16H24N2.C4H6O6; mol wt 394.46.
C 60.90%, H 7.67%, N 7.10%, O 24.34%.

Properties

Crystals, mp 64°.

Therapeutic Category

Antitussive.

Keywords

Antitussive