5200. Isopimaric Acid

Nomenclature

CAS number: 5835-26-7
[1R-(1α,4aβ,4bα,7α,10aα)]-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic acid; 13β-methyl-13-vinylpodocarp-7-ene-15-oic acid; miropinic acid.
C20H30O2; mol wt 302.45.
C 79.42%, H 10.00%, O 10.58%.

Description and references

Isoln from Dacrydium biforme Pilg., Podocarpaceae: Hosking, Brandt, Ber. 68, 1311 (1935); from the bled resin of Podocarpus ferrugineus, Podocarpaceae: Brandt, Neubauer, J. Chem. Soc. 1940, 683; from Pimus palustris Mill., Pinaceae: Harris, Sanderson, J. Am. Chem. Soc. 70, 2079, 2081 (1948). Identity of isopimaric and miropinic acids: Brossi, Jeger, Helv. Chim. Acta 33, 722 (1950). Structure: Antkowiak et al., J. Org. Chem. 27, 1930 (1962). Stereochemistry: Ireland, Newbould, ibid. 1931; Antkowiak et al., Can. J. Chem. 43, 1257 (1965); Bose et al., Indian J. Chem. 5, 228 (1967).

Chemical structure

Properties

Needles from methanol or ethanol, mp 160°. [α]D16 3.6° (10.4% soln in 1:1 alcohol:chloroform). Freely sol in chloroform, benzene; moderately sol in ether, alcohol; slightly sol in light petroleum. Absorption spectrum: Brossi, Jeger, loc. cit.