5251. Ixodin

Description and references

Hirudin-like anticoagulant from Ixodes ricinus L., Acari and other blood-sucking ticks: Sabbatani, Arch. Ital. Biol. 31, 37 (1899). Thrombokinase inhibitor. Extraction procedure: F. Markwardt, Blutgerinnungshemmende Wirkstoffe aus blutsaugenden Tieren (Jena, 1963) pp 88-92.

Properties

White powder. Soluble in 80% ethanol, 90% methanol and 75% acetone. Practically insol in ether. Stable at pH 1.0-12.0. Adsorbed on Amberlite IRC 50 (H-form). Acts like a high-molecular weight polypeptide. Attacked by papain.