Description and references

Neurohumoral hormone produced in the hypothalamus which stimulates the secretion of the pituitary hormones, LH (luteinizing hormone) and FSH (follicle-stimulating hormone) q.q.v., which in turn produce changes resulting in the induction of ovulation. Isoln from porcine hypothalamic extracts: A. V. Schally et al., Biochem. Biophys. Res. Commun. 43, 393 (1971). Structure: Matsuo et al., ibid. 1334; Baba et al., ibid. 44, 459 (1971); Burgus et al., C. R. Seances Acad. Sci. Ser. D 273, 1611 (1971). Solid phase synthesis: Monahan et al., ibid. 508; Monahan, Rivier, Biochem. Biophys. Res. Commun. 48, 1100 (1972); Coy et al., Methods Enzymol. 37, 416 (1975); D. H. Rich, S. K. Gurwara, Tetrahedron Lett. 1975, 301. Industrial prepn: Geiger et al., DE 2213737 (1973 to Hoechst). Confirmation of biological activity: A. V. Schally et al., Science 173, 1036 (1971). Pharmacokinetics: T. W. Redding, J. Clin. Endocrinol. Metab. 37, 626 (1973). Reviews of physiology and implications in fertility control: A. V. Schally et al., Fertil. Steril. 22, 703 (1971); R. Guillemin, Contraception 6, 1 (1972). Review of LH-RH and other hypothalamic hormones: A. V. Schally et al., Science 179, 341 (1973); A. V. Schally, ibid. 202, 18-28 (1978); of LH-RH and somatostatin, q.v.: S. M. McCann, Annu. Rev. Pharmacol. Toxicol. 22, 491-515 (1982). General reviews: J. Sandow, Clin. Endocrinol. 18, 571-592 (1983); S. M. McCann, J. Endocrinol. Invest. 6, 243-251 (1983).

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