5483. Lidofenin

Nomenclature

CAS number: 59160-29-1
N-(Carboxymethyl)-N-[2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]glycine; N-(2,6-dimethylacetanilide)iminodiacetic acid; N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid; [[(2,6-xylylcarbamoyl)methyl]imino]diacetic acid; HIDA.
C14H18N2O5; mol wt 294.30.
C 57.14%, H 6.16%, N 9.52%, O 27.18%.

Description and references

Iminodiacetic acid analog. Prepn of compd and 99mTc-complex: M. D. Loberg et al., BE 840556; eidem, US 4017596 (1976, 1977 both to Research Corp.); and imaging studies: M. D. Loberg et al., J. Nucl. Med. 17, 633 (1976). Structural studies: M. D. Loberg, A. T. Fields, Int. J. Appl. Radiat. Isot. 29, 167 (1978). Chromatographic determn of radiochemical purity: A. M. Zimmer et al., Eur. J. Nucl. Med. 7, 88 (1982). Biodistribution and clinical kinetics: J. Ryan et al., J. Nucl. Med. 18, 995 (1977). Clinical studies of diagnostic use as hepatobiliary imaging agent: H. S. Weissmann et al., Am. J. Roentgenol. 132, 523 (1979); R. W. Nicholson et al., Br. J. Radiol. 53, 878 (1980).

Chemical structure

Properties

Crystals from water, mp 201-203°. LD50 i.v. in male mice: 168 mg/kg (Ryan).

Derivative

99mTc-complex.

Nomenclature

99mTc-HIDA; TechneScan HIDA (Mallinckrodt).

Therapeutic Category

99mTc-complex as diagnostic aid (radioactive imaging agent).

Keywords

Lidofenin Complex with 99mTc : Diagnostic Aid (Radioactive Imaging Agent)