5490. Limaprost
Nomenclature
CAS number: 74397-12-9
(2E,11α,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic acid; 17S,20-dimethyl-trans-2,3-didehydro-PGE1; 9-oxo-11α,15α-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic acid; 17S-methyl-ω-homo-trans-Δ2-PGE1; ONO-1206; OP-1206; Opalmon (Ono); Prorenal (Dainippon). C22H36O5; mol wt 380.52.
C 69.44%, H 9.54%, O 21.02%.
Description and references
Derivative of prostaglandin E1, q.v. Prepn: M. Hayashi et al., DE 3002677 (1980 to Ono); eidem, US 4294849 (1981 to Warner-Lambert). Cardiovascular pharmacology in animals: T. Tsuboi et al., Arch. Int. Pharmacodyn. 247, 89 (1980). Effect on smooth muscle in vitro: P. G. Adaikan, S. M. M. Karim, Prostaglandins Med. 6, 449 (1981). Coronary vasodilating effects in primates: S. R. Kottegoda et al., Prostaglandins Leukotrienes Med. 8, 343 (1982). Clinical hemodynamics in chronic lung disease: T. Ishizaki et al., Chest 85, 382 (1984).
Properties
White crystals, mp 97-100°.Therapeutic Category
Antianginal.
Keywords
Antianginal; Prostaglandin/Prostaglandin Analog