5637. Lysine Acetylsalicylate

Nomenclature

CAS number: 62952-06-1
dl-Lysine mono[2-(acetyloxy)benzoate]; lysine monosalicylate acetate; aspirin lysine salt; LAS; Aspidol (Piam); Aspisol (Bayer); Delgesic (Karlspharma); Flectadol (Maggioni); Lysal (Gellini); Quinvet (Neopharmed); Venopirin (Green Cross); Vetalgina (ICC).
C15H22N2O6; mol wt 326.34.
C 55.21%, H 6.79%, N 8.58%, O 29.42%.

Description and references

Water soluble, injectable aspirin derivative. Prepn: FR 1295304 (1962 to Equilibre Biologique), C.A. 58, 1536f (1963). Prepn of d,l isomers and racemate: FR 2115060 (1972 to Metabio), C.A. 78, 75877k (1972). Comparison with aspirin: S. Rampon et al., Rhumatologie 24, 141 (1972). Pharmacokinetics: H. von Ross et al., Klin. Wochenschr. 56, 1119 (1978); F. Gentit, Gaz. Med. Fr. 86, 4539 (1979). Veterinary use as analgesic: P. Richez et al., J. Vet. Pharmacol. Ther. 2, 231 (1979); eidem, ibid. 3, 121 (1980). Analgesic activity in post-operative pain: K. Korttila et al., Br. J. Anaesth. 52, 613 (1980); in articular pain: C. Diaz et al., Clin. Ther. 4, 121 (1981). Use in treatment of premature labor: F. Wolff et al., Arch. Gynecol. 233, 15 (1982). Comparison with aspirin in production of gastromucosal damage: J.-F. Bretagne et al., Gastroenterol. Clin. Biol. 8, 28 (1984).

Chemical structure

Properties

Crystals from ethanol, mp 154-156°. Sol in water; slightly sol in ethanol. Insol in methanol, acetone, ether.

Therapeutic Category

Analgesic; antipyretic; anti-inflammatory.

Therapeutic Category (Veterinary)

Analgesic; antipyretic; anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic; Analgesic; Non-opioids; Salicylic Acid Derivatives