5651. Magaldrate

Nomenclature

CAS number: 74978-16-8
Aluminum magnesium hydroxide sulfate (Al5Mg10(OH)31(SO4)2) hydrate; magnesium aluminate hydrate; monalium hydrate; AY-5710; Dynese (Galen); Riopan (Ayerst); Ripon.

Description and references

Formerly treated as [Mg(OH)]4[(HO)4Al(OH)(HO)Al(OH)4].2H2O. Prepd by mixing together and allowing to react at 0° to 50° an alkali aluminate soln (contg 3-5 mols of Na2O or K2O per mol Al2O3) with a magnesium salt soln in such proportions that 1 g of Al combines with 0.9 to 3.0 g of Mg, and washing the pptd product: Hallmann, US 2923660 (1960 to Byk-Gulden Lomberg). Characterization: C. L. Peterson et al., Pharm. Res. 10, 998 (1993).

Properties

White, odorless, crystalline powder which contains the equivs of not <28.0% and not >39.0% MgO and not <17.0% and not >25.0% Al2O3.

Therapeutic Category

Antacid.

Keywords

Antacid