5712. Malotilate

Nomenclature

CAS number: 59937-28-9
1,3-Dithiol-2-ylidenepropanedioic acid bis(1-methylethyl) ester; diisopropyl 1,3-dithiol-2-ylidenemalonate; NKK-105; Hepation (Nippon Chemiphar); Kantec (Daiichi).
C12H16O4S2; mol wt 288.38.
C 49.98%, H 5.59%, O 22.19%, S 22.24%.

Description and references

Prepn from diisopropyl malonate: K. Taninaka et al., DE 2545569; eidem, US 4035387 (1976, 1977 both to Nihon Nohyaku); from the corresponding ketene mercaptide: H. Matsui et al., US 4327223 (1982 to Nihon Nohyaku). Effect on CCl4-induced liver injury in rats: Y. Imaizumi et al., Jpn. J. Pharmacol. 31, 15 (1981). Enhancement of rat liver protein synthesis: eidem, ibid. 32, 369 (1982). Pharmacokinetics and pharmacodynamics: M. Buhrer et al., Eur. J. Clin. Pharmacol. 30, 407 (1986). Clinical evaluation in liver cirrhosis: S. Takase et al., Gastroenterol. Jpn. 23, 639 (1988).

Chemical structure

Properties

Pale yellow crystals, mp 60.5°. Sol in benzene, cyclohexane, n-hexane, ether.

Therapeutic Category

Hepatoprotectant.

Keywords

Hepatoprotectant