5746. d-Mannitol Hexanitrate

Nomenclature

CAS number: 15825-70-4
Mannitol nitrate; nitromannite; nitromannitol; Medemanol; Dilangil; Moloid (Südmedica); Mannitrin; Manexin.
C6H8N6O18; mol wt 452.16.
C 15.94%, H 1.78%, N 18.59%, O 63.69%.

Description and references

Made by nitration of mannitol: Fleury et al., Mem. Poudres 31, 107 (1949).

Properties

Long needles in regular clusters from alc. mp 106-108°. Soluble in alc, in ether; insol in water. Explodes on percussion. Its stability at ordinary temps is such that it may be used commercially, but it is distinctly less stable than nitroglycerol at 75°. Its employ for pharmaceutical prepns is only in admixture with carbohydrate substances in dilutions corresponding to 1 part of mannitol hexanitrate to 9 or more parts of carbohydrate. In such dilutions mannitol hexanitrate is considered nonexplosive.

Therapeutic Category

Vasodilator.

Keywords

Vasodilator (Coronary)