5763. Mazipredone

Nomenclature

CAS number: 13085-08-0
(11β)-11,17-Dihydroxy-21-(4-methyl-1-piperazinyl)pregna-1,4-diene-3,20-dione; 11β,17α-dihydroxy-3,20-dioxo-21-(4-methyl-1-piperazinyl)pregna-1,4-diene; 11β,17-dihydroxy-21-(4-methyl-1-piperazinyl)-Δ1-progesterone.
C26H38N2O4; mol wt 442.59.
C 70.56%, H 8.65%, N 6.33%, O 14.46%.

Description and references

Prepn: Tuba et al., HU 150350 (1963 to Gedeon Richter), C.A. 60, 3057h (1964).

Chemical structure

Properties

Crystals from tetrahydrofuran + ligroin, dec 199°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 60-39-9
Depersolone.
C26H38N2O4.HCl; mol wt 479.05.
C 65.19%, H 8.21%, N 5.85%, O 13.36%, Cl 7.40%.

Properties

Crystals, dec 246°. Sol in water.

Therapeutic Category

Anti-inflammatory.

Keywords

Glucocorticoid