5784. Mecoprop

Nomenclature

CAS number: 7085-19-0
2-(4-Chloro-2-methylphenoxy)propanoic acid; (±)-2-[(4-chloro-o-tolyl)oxy]propionic acid; mechlorprop; MCPP; CMPP; RD-4593; Astix CMPP (Agrotec); Iso-Cornox (FBC); Compitox (M & B); Compitox Plus (M & B); Proponex-Plus (Shell).
C10H11ClO3; mol wt 214.65.
C 55.95%, H 5.17%, Cl 16.52%, O 22.36%.

Description and references

Prepn: M. E. Synerholm, P. W. Zimmerman, Contrib. Boyce Thompson Inst. 14, 91 (1945). Studies on plant growth regulation: C. H. Fawcett et al., Ann. Appl. Biol. 40, 231 (1953); and comparison of enantiomers: M. Matell, Kungl. Lantbruks-Hogsk. Ann. 20, 207 (1953); B. Aberg, ibid. 241. GLC determn: H. G. Higson, D. Butler, Analyst 85, 657 (1960). Crystal structure: G. Smith et al., Acta Crystallogr. B36, 992 (1980). Herbicidal activity: G. B. Lush, Proc. 3rd Br. Weed Control Conf. 625 (1956); E. L. Leafe, ibid. 633; B. Wallgren, Weeds Weed Contr. 24th Swedish Weed Conf. 30 (1983); of (+)-enantiomer: J. Toll, Weeds Weed Contr. 28th Swedish Weed Conf. 100 (1987). Degradation in soils: L. Lindholm et al., Acta Agric. Scand. 32, 429 (1982); A. E. Smith, Bull. Environ. Contam. Toxicol. 34, 656 (1985). Toxicological studies: M. R. Gurd et al., Food Cosmet. Toxicol. 3, 883 (1965); H. G. Verschuuren et al., Toxicology 3, 349 (1975); R. Roll, G. Matthiaschk, Arzneim.-Forsch. 33, 1479 (1983). EC-GLC determn in tissues and biological fluids: J. De Beer et al., Vet. Hum. Toxicol. 21, Suppl., 172 (1979). HPLC resolution of enantiomers: B. Blessington et al., J. Chromatogr. 396, 177 (1987).

Chemical structure

Properties

Solid, mp 93-94°. LD50 in rats (mg/kg): 1210 orally, 402 i.p. (Verschuuren).

Derivative

(+)-Form.

Nomenclature

Mecoprop-P; Duplosan KV (BASF).

Properties

Solid, mp 95-96°. [α]D25 +19° (alcohol).

Derivative

Sodium salt.
C10H11ClNaO3; mol wt 237.64.
C 50.54%, H 4.67%, Cl 14.92%, Na 9.67%, O 20.20%.

Properties

LD50 i.p. in rats, mice: 500, 600 mg/kg; orally in mice: 650 mg/kg (Gurd).

Derivative

Diethylamine salt.

Nomenclature

Mecopar.
C14H22ClNO3; mol wt 287.78.
C 58.43%, H 7.71%, Cl 12.32%, N 4.87%, O 16.68%.

Properties

LD50 in rats, mice (mg/kg): 1060 ±120, 600 ±35 orally; 350, 400 i.p. (Gurd).

Derivative

Potassium salt.

Nomenclature

Mecomec (PBI/Gordon); Hedonal MCPP (Bayer).
C10H11ClKO3; mol wt 253.74.
C 47.33%, H 4.37%, Cl 13.97%, K 15.41%, O 18.92%.

Use

Herbicide.