5794. Medrysone

Nomenclature

CAS number: 2668-66-8
(6α,11β)-11-Hydroxy-6-methylpregn-4-ene-3,20-dione; 11β-hydroxy-6α-methylprogesterone; 6α-methyl-11β-hydroxyprogesterone; hydroxymesterone; U-8471; HMS (Allergan).
C22H32O3; mol wt 344.49.
C 76.70%, H 9.36%, O 13.93%.

Description and references

Prepn and use as an intermediate: Sebek et al., Spero, Thompson, US 2864837 and US 2968655 (1958 and 1961, both to Upjohn). In treatment of ocular inflammation: Bedrossian, Arch. Ophthalmol. 81, 184 (1969).

Chemical structure

Properties

Crystals, mp 155-158°. [α]D +189° (in chloroform).

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid