5799. Mefenorex

Nomenclature

CAS number: 17243-57-1
N-(3-Chloropropyl)-α-methylbenzeneethanamine; N-(3-chloropropyl)-α-methylphenethylamine; 1-phenyl-2-(3-chloropropylamino)propane.
C12H18ClN; mol wt 211.73.
C 68.07%, H 8.57%, Cl 16.74%, N 6.62%.

Description and references

Prepn: Beschke et al., DE 1210873 (1966 to Hoffmann-La Roche), C.A. 64, 19486c (1966). Clinical pharmacology: P. Netter et al., Arzneim.-Forsch. 28, 1310 (1978). GC-MS determn in urine: A. Franceschini et al., J. Chromatogr. 541, 109 (1991). Pharmacokinetics and metabolism: S. Rendic et al., Eur. J. Drug Metab. Pharmacokinet. 19, 107 (1994). Review: J. Engel et al., Drug Alcohol Depend. 17, 229-234 (1986).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 5586-87-8
Ro-4-5282; Incital (Fabre Santé); Pondinil (Roche); Pondinol (Roche).
C12H18ClN.HCl; mol wt 248.19.
C 58.07%, H 7.72%, Cl 28.57%, N 5.64%.

Properties

Solid, mp 128-130°.

Note

This is a controlled substance (stimulant): 21 CFR, 1308.14.

Therapeutic Category

Anorexic.

Keywords

Anorexic