5823. Melitracen

Nomenclature

CAS number: 5118-29-6
3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine; N,N,10,10-tetramethyl-Δ9(10H),γ-anthracenepropylamine; 9,10-dihydro-10,10-dimethyl-9-(3-dimethylaminopropylidene)anthracene; 9-[3-(dimethylamino)propylidene]-10,10-dimethyl-9,10-dihydroanthracene; N,N-dimethyl-3-(10,10-dimethyl-9(10H)-anthrylidene)propylamine.
C21H25N; mol wt 291.43.
C 86.55%, H 8.65%, N 4.81%.

Description and references

Prepn of the hydrochloride: Holm, Acta Chem. Scand. 17, 2437 (1963); idem, GB 939856 corresp to US 3177209 (1963, 1965, both to Kefalas A/S). Crystal structure: J. Lopez de Lerma et al., Acta Crystallogr. B35, 1739 (1979). Toxicity data: P. V. Petersen et al., Acta Pharmacol. Toxicol. 24, 121 (1966).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 10563-70-9
U-24973A; Melixeran (Lusofarmaco); Trausabun (Promonta); Dixeran (Lundbeck).
C21H25N.HCl; mol wt 327.89.
C 76.92%, H 7.99%, N 4.27%, Cl 10.81%.

Properties

Crystals from acetone, mp 245-248°. LD50 i.v. in mice: 52 mg/kg (Petersen).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics