5864. Mequitazine

Nomenclature

CAS number: 29216-28-2
10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine; 10-(3-quinuclidinylmethyl)phenothiazine; LM-209; Butix (Fabre); Metaplexan (Rhne-Poulenc); Mircol (Rhne-Poulenc); Primalan (Inava); Zesulan (Toyo Jozo).
C20H22N2S; mol wt 322.47.
C 74.49%, H 6.88%, N 8.69%, S 9.94%.

Description and references

Prepn: G. Gueremy et al., DE 2009555 corresp to US 3987042 (1970, 1976 to Sogeras). Absorption, distribution, and excretion: A. Uzan et al., Xenobiotica 6, 633 (1976). Biotransformation: eidem, ibid. 649. Pharmacologic study: eidem, J. Pharm. Pharmacol. 31, 701 (1979). Clinical studies: J. Blamoutier, Curr. Med. Res. Opin. 5, 366 (1978); P. Laugier, M. Orusco, ibid. 371.

Chemical structure

Properties

Crystals from acetonitrile, mp 130-131°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Phenothiazines