5961. Metharbital

Nomenclature

CAS number: 50-11-3
5,5-Diethyl-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5,5-diethyl-1-methylbarbituric acid; Gemonil (Abbott).
C9H14N2O3; mol wt 198.22.
C 54.53%, H 7.12%, N 14.13%, O 24.21%.

Description and references

Prepn: Halpern, Jones, J. Am. Pharm. Assoc. 38, 352 (1949); Snyder, Link, J. Am. Chem. Soc. 75, 1881 (1953).

Chemical structure

Properties

Crystals from benzene + petr ether, mp 155°. Solubility (g/100 ml soln) in water 0.12; in alcohol 4.3; in ether 2.6. pH of satd aq solns: 5.6-5.7. pK 8.45: Fox, Shugar, Bull. Soc. Chim. Belg. 61, 44 (1952).

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant