5984. Methopterin

Nomenclature

CAS number: 2410-93-7
N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-l-glutamic acid; N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]glutamic acid; 10-methylpteroylglutamic acid; N10-methylfolic acid.
C20H21N7O6; mol wt 455.42.
C 52.75%, H 4.65%, N 21.53%, O 21.08%.

Description and references

Prepn: Cosulich, Smith, J. Am. Chem. Soc. 70, 1922 (1948); Cosulich, US 2563707 (1951 to Am. Cyanamid).

Chemical structure

Derivative

Monohydrate.

Properties

Yellow spherulites. uv max (0.1N NaOH): 255, 302, 368 nm (ε × 103 26, 27, 9); (0.1N HCl): 307 nm (ε × 103 25).