5998. Methoxyphenamine

Nomenclature

CAS number: 93-30-1
2-Methoxy-N,α-dimethylbenzeneethanamime; o-methoxy-N,α-dimethylphenethylamine; β-(o-methoxyphenyl)isopropylmethylamine; α-(2-methoxyphenyl)-β-methylaminopropane.
C11H17NO; mol wt 179.26.
C 73.70%, H 9.56%, N 7.81%, O 8.93%.

Description and references

β-Adrenergic agonist. Prepn: Woodruff et al., J. Am. Chem. Soc. 62, 922 (1940); Heinzelman, ibid. 75, 921 (1953); Morishita, JP 61 2921 (1961 to Nippon Shinyaku), C.A. 55, 24677f (1961).

Chemical structure

Properties

Oil, bp2 97-99°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 5588-10-3
Orthoxine (Roberts).
C11H17NO.HCl; mol wt 215.72.
C 61.24%, H 8.41%, N 6.49%, O 7.42%, Cl 16.43%.

Properties

Bitter crystals from ether + alcohol, mp 129-131°. Freely sol in water, alcohol, chloroform. Slightly sol in ether, benzene. pH 5.3-5.7 (5% aq soln).

Therapeutic Category

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator