Description and references

Prodrug of δ-aminolevulinic acid, q.v.; induces production of intracellular protoporphyrin IX. Prepn: S. I. Zav'yalov, A. G. Zavozin, Bull. Acad. Sci. USSR Div. Chem. Sci. 36, 1663 (1987). Porphyrin enrichment in solar keratoses: C. Fritsch et al., Photochem. Photobiol. 68, 218 (1998). Clinical trial in photodynamic therapy of basal cell carcinomas: A. M. Soler et al., Br. J. Dermatol. 145, 467 (2001); C. Vinciullo et al., Br. J. Dermatol. 152, 765 (2005); in actinic keratosis: R. M. Szeimies et al., J. Am. Acad. Dermatol. 47, 258 (2002). Review of pharmacology and clinical experience: M. A. A. Siddiqui et al., Am. J. Clin. Dermatol. 5, 127-137 (2004).

Derivative