6050. 5-Methylcytosine

Nomenclature

CAS number: 554-01-8
4-Amino-5-methyl-2(1H)-pyrimidinone.
C5H7N3O; mol wt 125.13.
C 47.99%, H 5.64%, N 33.58%, O 12.79%.

Description and references

Occurs in a nucleic acid obtained from tubercle bacillus. Isoln: Johnson, Coghill, J. Am. Chem. Soc. 47, 2838 (1925). Synthesis from ethyl bromide addition product of thiourea and from ethyl formyl propionate: Wheeler, Johnson, Am. Chem. J. 29, 492 (1903).

Chemical structure

Properties

Prisms from water, may contain mol H2O. mp 270° (effervescence). One gram dissolves in 29 ml water.