6053. p-Methyldiphenhydramine

Nomenclature

CAS number: 19804-27-4
N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine; N,N-dimethyl-2-[(p-methyl-α-phenylbenzyl)oxy]ethylamine; β-dimethylaminoethyl 4-methylbenzhydryl ether; p-methylbenzhydryl 2-dimethylaminoethyl ether; Neo-Benodine; Toladryl.
C18H23NO; mol wt 269.38.
C 80.26%, H 8.61%, N 5.20%, O 5.94%.

Description and references

Prepn: Rieveschl, US 2527962 (1950 to Parke, Davis); GB 683483 (1952 to Fabriken Brocades-Stheeman & Pharmacia).

Chemical structure

Derivative

Hydrochloride.
C18H23NO.HCl; mol wt 305.84.
C 70.69%, H 7.91%, N 4.58%, O 5.23%, Cl 11.59%.

Properties

Crystals from acetone, mp 150-152° (free base bp0.1 143°).

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Aminoalkylethers