6076. N-Methylformamide

Nomenclature

CAS number: 123-39-7
N-Monomethylformamide; NMF; MMF; NSC-3051.
C2H5NO; mol wt 59.07.
C 40.67%, H 8.53%, N 23.71%, O 27.09%.
HCONHCH3.

Description and references

Prepn: A. Gautier, Ann. 151, 239 (1869); G. F. D'Alelio, E. E. Reid, J. Am. Chem. Soc. 59, 109 (1937); J. A. Marsella, G. P. Pez, J. Mol. Catal. 35, 65 (1986); J. J. Cappon et al., Recl. Trav. Chim. Pays-Bas 113, 318 (1994). Dielectric spectrum: J. Barthel et al., Chem. Phys. Lett. 167, 62 (1990). Toxicology: S. P. Langdon et al., Toxicology 34, 173 (1985). Review of metabolism, toxicity, and pharmacology: G. L. Kennedy, Jr., Crit. Rev. Toxicol. 17, 129-182 (1986). Review of antitumor activity and clinical evaluation: K. Clagett-Carr et al., J. Clin. Oncol. 6, 906-918 (1988).

Properties

mp 5.4°. bp 180-185°. bp90 131°. d425 0.9961. Sol in acetone, alcohol, water. LD50 in mice (mg/kg): 2300 i.p.; 2600 orally; 1580 i.v.; 2700 i.m. (Langdon).

Use

Solvent.