6113. Methyl Propyl Ether

Nomenclature

CAS number: 557-17-5
1-Methoxypropane; propyl methyl ether; Neothyl.
C4H10O; mol wt 74.12.
C 64.82%, H 13.60%, O 21.59%.

Description and references

Prepd by passing a mixture of methyl and propyl alcohol through a hot layer of β-naphthalenesulfonic or benzenesulfonic acids: Krafft, Ber. 26, 2832 (1893); DE 69115; Frdl. III, 11. Laboratory prepn from sodium propylate and methyl iodide: Chancel, Ann. 151, 305 (1869); Michael, Wilson, Ber. 39, 2573 (1906); and water solubility: G. M. Bennett, W. G. Phillip, J. Chem. Soc. 1928, 1930 DOI. Clinical trial as anesthetic: E. A. Parmenter, Can. Anaesth. Soc. J. 9, 424 (1962) PubMed.

Chemical structure

Properties

Mobile liquid. Flammable. d40 0.7494; d413 0.7356. bp761 38.8°. nD14.3 1.36019. Soly in water (25°): 5 ml/100 ml H2O. Miscible with alc, ether. Absorbs some water. Oil/water coefficient 10 ± 1. Anesthetic index 2.5.

Therapeutic Category

Anesthetic (inhalation).

Keywords

Anesthetic (Inhalation)