6149. Metopimazine

Nomenclature

CAS number: 14008-44-7
1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide; 1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide; 10-[3-(4-carbamoylpiperidino)propyl]-2-(methanesulfonyl)phenothiazine; 1-[3-[2-(methylsulfonyl)phenothiazin-10-yl]propyl]-4-piperidinecarboxamide; EXP-999; RP-9965; Vogalene (Thraplix).
C22H27N3O3S2; mol wt 445.60.
C 59.30%, H 6.11%, N 9.43%, O 10.77%, S 14.39%.

Description and references

Prepn: Jacob, Robert, DE 1092476 (to Rhne-Poulenc), C.A. 56, 8723h (1962). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

Solid, mp 170-171°. LD50 in male rats (mg/kg): 976 orally, 1080 s.c. (Goldenthal).

Therapeutic Category

Antiemetic.

Keywords

Antiemetic