6184. Midodrine

Nomenclature

CAS number: 42794-76-3
2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide; 1-(2′,5′-dimethoxyphenyl)-2-glycinamidoethanol.
C12H18N2O4; mol wt 254.28.
C 56.68%, H 7.14%, N 11.02%, O 25.17%.

Description and references

α-Adrenergic agonist. Prepn: K. Wismayr et al., AT 241435; eidem, US 3340298 (1965, 1967 both to OSSW). Hemodynamic effects: G. Hitzenberger et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 7, 323 (1973). Pharmacodynamic actions: H. Pittner et al., Arzneim.-Forsch. 26, 2145 (1976). Plasma levels: N. Kolassa et al., Arch. Int. Pharmacodyn. Ther. 238, 96 (1979). Use in ejaculation disorders: D. Jonas et al., Eur. Urol. 5, 184 (1979); in circulatory disorders: H. Sazovsky, H. Pittner, Fortschr. Med. 97, 733 (1979). Synthesis of potential metabolites: T. Kappe, W. Witoszynaky, Arch. Pharm. 308, 339 (1975).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 3092-17-9
ST-1085; Amatine (Roberts); Gutron (Nycomed); Hipertan (Gramon); Metligine (Taisho); ProAmatine (Roberts).
C12H18N2O4.HCl; mol wt 290.74.
C 49.57%, H 6.59%, N 9.64%, O 22.01%, Cl 12.19%.

Properties

Crystals, mp 192-193°.

Therapeutic Category

Antihypotensive.

Keywords

α-Adrenergic Agonist; Antihypotensive