6208. Mirtazapine

Nomenclature

CAS number: 61337-67-5
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine; 6-azamianserin; mepirzepine; Org-3770; Remeron (Organon); Zispin (Organon).
C17H19N3; mol wt 265.35.
C 76.95%, H 7.22%, N 15.84%.

Description and references

α2-Adrenergic blocker; analog of mianserin, q.v. Prepn: W. J. Van der Burg, DE 2614406; idem, US 4062848 (1976, 1977 both to AKZO). GC determn in plasma: J. E. Paanakker, H. J. M. Van Hal, J. Chromatogr. 417, 203 (1987). Pharmacology and mechanism of action study: T. De Boer et al., Neuropharmacology 27, 399 (1988). Clinical comparison with amitriptyline, q.v.: W. T. Smith et al., Psychopharmacol. Bull. 26, 191 (1990). Review of clinical experience in mood and anxiety disorders: M. J. Ostacher et al., Expert Rev. Neurother. 3, 425-433 (2003); and of clinical pharmacokinetics, safety and efficacy: A. Szegedi, N. Schwertfeger, Expert Opin. Pharmacother. 6, 631-641 (2005).

Chemical structure

Properties

White crystals from petr ether, mp 114-116°. Sol in methanol and chloroform.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tetracyclics