6233. Molindone

Nomenclature

CAS number: 7416-34-4
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one; 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one.
C16H24N2O2; mol wt 276.37.
C 69.53%, H 8.75%, N 10.14%, O 11.58%.

Description and references

Prepn: BE 670798; I. J. Pachter, K. Schoen, US 3491093 (1966, 1970 both to Endo). Pharmacology: Sugerman, Herrmann, Clin. Pharmacol. Ther. 8, 261 (1967); Claghorn, Curr. Ther. Res. 11, 524 (1969); Guerrero-Figueroa et al., ibid. 15, 508 (1973). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

Crystals, mp 180-181°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 15622-65-8
EN-1733A; Lidone (Abbott); Moban (Endo).

Properties

LD50 orally in rats: 261 mg/kg (Goldenthal).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic