6241. Mometasone Furoate

Nomenclature

CAS number: 83919-23-7
(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 9,21-dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-(2-furoate); Sch-32088; Asmanex (Schering-Plough); Elocon (Schering-Plough); Nasonex (Schering-Plough).
C27H30Cl2O6; mol wt 521.43.
C 62.19%, H 5.80%, Cl 13.60%, O 18.41%.

Description and references

Topical corticosteroid. Prepn: E. L. Shapiro, EP 57401; idem, US 4472393 (1982, 1984 both to Schering Corp.); E. L. Shapiro et al., J. Med. Chem. 30, 1581 (1987). LC-MS-MS determn in plasma: S. Sahasranaman et al., J. Chromatogr. B 819, 175 (2005). Clinical trial in psoriasis: R. S. Medansky et al., Semin. Dermatol. 6, 94 (1987); in seasonal allergic rhinitis: D. Graft et al., J. Allergy Clin. Immunol. 98, 724 (1996).

Chemical structure

Properties

Crystals from aq methanol, mp 218-220°. [α]D26 +58.3° (dioxane). uv max (methanol): 247 nm (ε 26300). Practically insol in water. Slightly sol in octanol; moderately sol in ethyl alcohol.

Therapeutic Category

Anti-inflammatory.

Keywords

Glucocorticoid