6263. Moperone

Nomenclature

CAS number: 1050-79-9
1-(4-Fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]-1-butanone; p-fluoro-4-(4′-hydroxy-4′-p-tolylpiperidino)butyrophenone; p-fluoro-4-(4′-hydroxy-4′-p-methylphenylpiperidino)butyrophenone; 1-(3′-p-fluorobenzoylpropyl)-4-hydroxy-4-p-tolylpiperidine; ω-(4-hydroxy-4-p-tolylpiperidino)-p-fluorobutyrophenone; methylperidol; R-1658.
C22H26FNO2; mol wt 355.45.
C 74.34%, H 7.37%, F 5.34%, N 3.94%, O 9.00%.

Description and references

Prepn: Janssen et al., J. Med. Pharm. Chem. 1, 281 (1959); Janssen, GB 881893 (1961).

Chemical structure

Properties

Crystals, mp 118-119.5°. uv max: 246.5 nm (ε 12200).

Derivative

Hydrochloride.

Nomenclature

CAS number: 3871-82-7
Luvatren (Cilag-Chemie).
C22H26FNO2.HCl; mol wt 391.91.
C 67.42%, H 6.94%, F 4.85%, N 3.57%, O 8.16%, Cl 9.05%.

Properties

Crystals from isopropyl ether, mp 216-218°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones