6411. 1-Naphthylisothiocyanate

Nomenclature

CAS number: 551-06-4
1-Isothiocyanatonaphthalene; isothiocyanic acid 1-naphthyl ester; ANIT.
C11H7NS; mol wt 185.24.
C 71.32%, H 3.81%, N 7.56%, S 17.31%.

Description and references

Prepn: Cymerman-Craig et al., Org. Synth. coll. vol. IV, 700 (1963); Jochims, Ber. 101, 1746 (1968). Has been used with pyrethrum as insecticide. Toxicity studies: Schwartz, Warren, Public Health Rep. 54, 1426 (1939); Ambrose, Miller, Fed. Proc. 2, 74 (1943); Becker, Plaa, Toxicol. Appl. Pharmacol. 7, 804 (1965); Capizzo, Roberts, ibid. 17, 262 (1970).

Chemical structure

Properties

White needles; practically odorless and tasteless, mp 58°. Insol in water. Freely sol in ether, benzene, hot alcohol, acetone, carbon tetrachloride, olive oil, petr ether. LD50 orally in mice: 245 mg/kg (Becker, Plaa).

Caution

Hepatotoxic; may cause dermatitis.