6445. Nemifitide

Nomenclature

CAS number: 173240-15-8
4-Fluoro-l-phenylalanyl-(4R)-4-hydroxy-l-prolyl-l-arginylglycyl-l-tryptophanamide; 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2; netamifide.
C33H43FN10O6; mol wt 694.76.
C 57.05%, H 6.24%, F 2.73%, N 20.16%, O 13.82%.

Description and references

Synthetic pentapeptide produced by modification of melanocyte stimulating inhibitory factor. Prepn: H. B. Abajian, et al., WO 9530430; eidem, US 5589460 (1995, 1996 both to Innapharma). Structure activity study: J. J. Hlavka, J. Appl. Res. 2, 58 (2002). Clinical pharmacokinetics: J. P. Feighner et al., Biopharm. Drug Dispos.. 23, 33 (2002); G. Nicolau et al., ibid. 26, 379 (2005). Clinical evaluation: eidem, Int. J. Neuropsychopharmacol. 6, 207 (2003). Review of development and therapeutic potential: J. Dingemanse, Curr. Opin. Investig. Drugs 4, 859-862 (2003).

Chemical structure

Derivative

Bis(trifluoroacetate).

Nomenclature

CAS number: 204992-09-6
Nemifitide ditriflutate; INN-00835.
C33H43FN10O6.2C2HF3O2; mol wt 922.80.
C 48.16%, H 4.92%, F 14.41%, N 15.18%, O 17.34%.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant