6478. Neticonazole

Nomenclature

CAS number: 130726-68-0
1-[(1E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole.
C17H22N2OS; mol wt 302.43.
C 67.51%, H 7.33%, N 9.26%, O 5.29%, S 10.60%.

Description and references

Antifungal that inhibits cell wall synthesis. Prepn: M. Ogawa et al., EP 227011; eidem, US 4740601 (1987, 1988 both to SS Pharm.); and antifungal activity: M. Ogawa et al., Chem. Pharm. Bull. 39, 2301 (1991). Clinical study in tinea pedis: R. Tsuboi et al., Int. J. Dermatol. 35, 371 (1996).

Chemical structure

Properties

Colorless crystals from isopropyl ether, mp 37-39°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 130773-02-3
SS-717; Atolant (Takeda).
C17H22N2OS.HCl; mol wt 338.90.
C 60.25%, H 6.84%, N 8.27%, O 4.72%, S 9.46%, Cl 10.46%.

Properties

Colorless columns from acetonitrile, mp 145-147°.

Therapeutic Category

Antifungal (synthetic).

Keywords

Antifungal (Synthetic); Imidazoles