6481. Netropsin
Nomenclature
Description and references
Basic oligopeptide antibiotic produced by Streptomyces netropsis with wide range of antimicrobial activity. Prepn and antibacterial spectrum: A. C. Finlay et al., J. Am. Chem. Soc. 73, 341 (1951); and trypanocidal activity: C. Cosar et al., Compt. Rend. 234, 1498 (1952). Antiviral activity: F. M. Schabel et al., Proc. Soc. Exp. Biol. Med. 83, 1 (1953). Identity with sinanomycin: K. Watanabe, J. Antibiot. 9A, 102 (1956). Structural studies: M. Julia, N. Joseph, Compt. Rend. 243, 961 (1956). Structure: C. W. Waller et al., J. Am. Chem. Soc. 79, 1265 (1957). Revised structure: M. Julia, N. Préau-Joseph, Compt. Rend. 257, 1115 (1963); eidem, Bull. Soc. Chim. Fr. 1967, 4348. Specific binding to DNA: Ch. Zimmer et al., J. Mol. Biol. 58, 329 (1971); K. Zakrzewska et al., Nucleic Acids Res. 11, 8825, 8841 (1983). Use in gradient separation of DNA: K. M. Tatti et al., Anal. Biochem. 89, 561 (1978). Selective blocking of DNAase I cleavage: Ch. Zimmer et al., Nucleic Acids Res. 8, 2999 (1980). Review of activity: F. E. Hahn in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 79-100. Review of effect on DNA structure and function: Ch. Zimmer, Prog. Nucleic Acid Res. Mol. Biol. 15, 285-318 (1975).
