6497. Niceritrol

Nomenclature

CAS number: 5868-05-3
3-Pyridinecarboxylic acid 2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl ester; nicotinic acid neopentanetetrayl ester; pentaerythritol tetranicotinate; 8-AL; Perycit (Bofors); Bufor (Bofors).
C29H24N4O8; mol wt 556.52.
C 62.59%, H 4.35%, N 10.07%, O 23.00%.

Description and references

Prepn: FR M2046 (1963 to Soc. d'Etudes et de Recherches Pharmacotechniques), C.A. 60, 10656e (1964); GB 1022880; GB 1053689 (1966, 1967 to Aktiebolag Bofors), C.A. 64, 19708d (1966), C.A. 66, 104907e (1967); Kuriyama, Kudo, JP 67 2359 (1967 to Yoshitomi), C.A. 66, 115935p (1967). Acute toxicity data: T. Sugawara et al., Oyo Yakuri 14, 741 (1977), C.A. 88, 131005v (1977).

Chemical structure

Properties

Crystals, mp reported as 160-162° and as 163-164°. LD50 in mice, rats (g/kg): >20, >20 orally; >5, >5 s.c.; >5, >5 i.p.; in rabbits (g/kg): >10 orally; >5 i.p. (Sugawara).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Nicotinic Acid Derivatives