6519. Niclosamide

Nomenclature

CAS number: 50-65-7
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; 2′,5-dichloro-4′-nitrosalicylanilide; 5-chloro-N-(2′-chloro-4′-nitrophenyl)salicylamide; 5-chlorosalicyloyl-(o-chloro-p-nitranilide); N-(2′-chloro-4′-nitrophenyl)-5-chlorosalicylamide; Bayer 2353; Cestocide (Bayer); Niclocide (Miles); Ruby (Spencer); Trédémine (RPR); Yomesan (Bayer).
C13H8Cl2N2O4; mol wt 327.12.
C 47.73%, H 2.47%, Cl 21.68%, N 8.56%, O 19.56%.

Description and references

Prepn: GB 824345 (1959 to Bayer), C.A. 54, 15822b (1960). See also: E. Schraufst"atter, R. G"onnert, US 3079297; R. Strufe et al., US 3113067 (both 1963 to Bayer); Bekhli et al., Med. Prom. SSSR 1965, 25.

Chemical structure

Properties

Pale yellow crystals, mp 225-230°. Practically insol in water. Sparingly sol in ethanol, chloroform, ether.

Derivative

Ethanolamine salt.

Nomenclature

CAS number: 1420-04-8
Clonitrilide; Bayluscid (Bayer).
C13H8Cl2N2O4.C2H7NO; mol wt 388.20.
C 46.41%, H 3.89%, Cl 18.27%, N 10.82%, O 20.61%.

Properties

Yellow-brown solid, mp 204°.

Use

The ethanolamine salt as a molluscicide.

Therapeutic Category

Anthelmintic (Cestodes).

Therapeutic Category (Veterinary)

Anthelmintic (Cestodes).

Keywords

Anthelmintic (Cestodes)