6533. Nifurfoline

Nomenclature

CAS number: 3363-58-4
3-(4-Morpholinylmethyl)-1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione; 3-(morpholinomethyl)-1-[(5-nitrofurfurylidene)amino]hydantoin; Urbac (Merck-Clévenot).
C13H15N5O6; mol wt 337.29.
C 46.29%, H 4.48%, N 20.76%, O 28.46%.

Description and references

Prepn: J. A. Bofill-Auge, J. M. Espinos-Taya, ES 297087 (1964), C.A. 63, 11572e (1966); GB 1245095 (1971 to Esteve), C.A. 75, 121382h (1971).

Chemical structure

Properties

Yellow cryst, mp 206°; also reported as mp 194-196°, J. Klosa, H. Starke, DD 508615 (1966), C.A. 66, 65501w (1967).

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Nitrofurans