6565. Nisoldipine

Nomenclature

CAS number: 63675-72-9
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester; isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridinecarboxylate; 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine; Bay k 5552; Baymycard (Bayer); Sular (Zeneca); Syscor (Bayer); Zadipina (Zambeletti).
C20H24N2O6; mol wt 388.41.
C 61.85%, H 6.23%, N 7.21%, O 24.72%.

Description and references

Dihydropyridine calcium channel blocker. Prepn: E. Wehinger et al., DE 2549568; eidem, US 4154839 (1977, 1979 both to Bayer). Pharmacology: S. Kazda et al., Arzneim.-Forsch. 30, 2144 (1980). Hemodynamics: A. Vogt et al., ibid. 2162. Series of articles on pharmacokinetics: ibid. 38, 1093-1110 (1988). Reviews of pharmacology and clinical efficacy: H. A. Friedel, E. M. Sorkin, Drugs 36, 682-731 (1988); J. Mitchell et al., J. Clin. Pharmacol. 33, 46-52 (1993).

Chemical structure

Properties

Crystals from ethanol, mp 151-152°.

Therapeutic Category

Antihypertensive; antianginal.

Keywords

Antianginal; Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives