6569. Nithiazide

Nomenclature

CAS number: 139-94-6
N-Ethyl-N′-(5-nitro-2-thiazolyl)urea; Hepzide (Merck & Co.).
C6H8N4O3S; mol wt 216.22.
C 33.33%, H 3.73%, N 25.91%, O 22.20%, S 14.83%.

Description and references

Prepd by the condensation of ethyl isocyanate with 2-amino-5-nitrothiazole in toluene: Cuckler et al., Proc. Soc. Exp. Biol. Med. 92, 483 (1956); O'Neill et al., US 2755285 (1956 to Merck & Co.).

Chemical structure

Properties

Crystals, dec 228°. pKa 7.3. Practically insol in water: 3 mg/100 ml.

Derivative

Sodium salt.

Properties

Orange plates. Soly in water: 8 g/100 ml. Aq solns are alkaline and unstable.

Derivative

Potassium salt.

Properties

Crystals. Soly in water: 3 g/l00 ml. Aq solns are more stable than those of the Na salt.

Therapeutic Category (Veterinary)

Antiprotozoal.