6598. Nitrofen

Nomenclature

CAS number: 1836-75-5
2,4-Dichloro-1-(4-nitrophenoxy)benzene; 2,4-dichlorophenyl-p-nitrophenyl ether; nitraphen; nitrophen; nitrofene; FW-925; TOK (Rohm & Haas).
C12H7Cl2NO3; mol wt 284.09.
C 50.73%, H 2.48%, Cl 24.96%, N 4.93%, O 16.90%.

Description and references

Selective pre- and post-emergence herbicide. Prepn: H. F. Wilson, H. M. Dougal, US 3080225 (1963 to Rohm & Haas). Toxicity studies: A. M. Ambrose et al., Toxicol. Appl. Pharmacol. 19, 263 (1971). Carcinogenicity studies: J. F. Robens, Vet. Hum. Toxicol. 22, 328 (1980). Review of carcinogenic risk: IARC Monographs 30, 271-282 (1983).

Chemical structure

Properties

Crystalline solid, mp 70-71°. Vapor pressure at 40°: 8 × 10-6 mm Hg. Soly in water at 22°: 0.7-1.2 ppm. LD50 orally in rats: 3.58 g/kg (Ambrose).

Caution

This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-192.

Use

Formerly as herbicide.