6640. N-Nitrosomorpholine

Nomenclature

CAS number: 59-89-2
4-Nitrosomorpholine; NMOR.
C4H8N2O2; mol wt 116.12.
C 41.37%, H 6.94%, N 24.12%, O 27.56%.

Description and references

Prepn: L. Knorr, Ann. 301, 1 (1898); F. Chapman, J. Chem. Soc. 1949, 1631; G. Oláh et al., Ber. 89, 2374 (1956). Metabolism: B. W. Stewart, P. N. Magee, Biochem. J. 126, 21P (1972). Carcinogenicity studies: H. Druckrey et al., Naturwissenschaften 48, 134 (1961); P. Bannasch, H.-A. Müller, Arzneim.-Forsch. 14, 805 (1964); IARC Monographs 17, 263 (1978).

Chemical structure

Properties

Yellow crystals, mp 29°. bp25 139-140°; bp747 224-224.5°. Sol in water. LD50 orally in rats: 282 mg/kg (Druckrey).

Caution

This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-205.